Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis.
Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is g...
متن کاملDemyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter.
Gray matter (GM) lesions are recognized as important components of the pathology of multiple sclerosis (MS), and involvement of the deep gray matter (DGM) is suggested by magnetic resonance imaging. The aims of this study were to determine the frequency and distribution of lesions and characterize the inflammatory and neurodegenerative changes in DGM of MS patients. Histochemistry, immunohistoc...
متن کاملMultiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron
In multiple sclerosis (MS), diffuse degenerative processes in the deep grey matter have been associated with clinical disabilities. We performed a systematic study in MS deep grey matter with a focus on the incidence and topographical distribution of lesions in relation to white matter and cortex in a total sample of 75 MS autopsy patients and 12 controls. In addition, detailed analyses of infl...
متن کاملNeurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.
Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., L...
متن کاملThe link of inflammation and neurodegeneration in progressive multiple sclerosis
Progressive multiple sclerosis (MS) is characterized clinically by the accumulation of neurological disability without unequivocal recovery. Understanding the mechanisms that determine entering in this stage of the disease is a great challenge in order to identify potential therapeutic targets. Recent advances in defining more accurately the progressive phenotype of MS, have concluded that diff...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 2007
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2006.11.015